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What are the symptoms of lupus nephritis in the later stage?

2017-10-24 17:06

Lupus nephritis belongs to immune complex nephritis, which is caused by systemic lupus erythematosus and renal involvement, mainly for the deposition of antigen antibody complex in the kidney to cause kidney disease, is one of the main causes of death are common complications of systemic lupus erythematosus and systemic lupus erythematosus. This disease is more common in women, is a chronic systemic autoimmune disease, the course of disease in order to alleviate the disease and alternating acute attack.

Lupus nephritis is an autoimmune disease, and its precipitating factors may be related to genetic factors, patients' personal constitution and environmental factors. Research shows that the genetic susceptibility to systemic lupus erythematosus can be located in sixth pairs of chromosomes, and patients with relative high incidence, identical incidence rate can be as high as 69%, both of which suggest that the incidence of systemic lupus erythematosus and genetic factors. In addition, the phenotype is determined by genetic and environmental factors, if genetic factors only show the susceptible patients have the disease tendency, so the environmental factors in the disease promoting in plays an important role.

Lupus nephritis can cause glomerular lesions in the kidneys. Examination of the patient's kidney showed an immune complex, which is a basic lesion of the disease. The immune complex can be deposited in the subepithelial, basement membrane, and mesangial regions. In addition, we can see the proliferation of the mesentery, endothelium and epithelial cells, swelling and segmental capillary necrosis. The patient still can appear the symptom such as albuminuria, hematuria. The reason is that the glomerular filtration rate declines after the occurrence of the glomerular lesion, the endothelial damage, the filtration membrane damage, the function decrease, the urinary protein content increases, and the red blood cell overflows into the urine, thus forming proteinuria and hematuria.

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