Thin basement membrane nephropathy

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Thin basement membrane nephropathy

2017-12-12 15:13

Thin basement membrane nephropathy is based on persistent microscopic hematuria as the main clinical manifestation of the process of good autosomal genetic disease. Can occur at any age, male to female ratio of 1: (2-3). The disease is due to chromosomal abnormalities, studies have shown that the genetic way for autosomal dominant inheritance. Pathogenesis of the medical profession is not very clear, the current speculation and basement membrane development is not mature. Clinical erythrocyte phase microscopy often shows typical glomerular hematuria, ranging in size and shape.

Other laboratory tests, such as kidney B ultrasound, intravenous pyelography, middle urinary culture, serum immunology (C3, immunoglobulin, anti-nuclear antibodies, etc.) and liver function tests and other abnormalities found; light microscopy , Normal or mild mesangial proliferative glomerulonephritis; immunofluorescence is often negative; electron microscopic ultrastructural observation showed diffuse glomerular basement membrane thinning (more than 1/3 of the normal GBM thickness), is the only disease Or important pathological features. As the majority of patients with this disease and no clear family, so it will be attributed to the primary glomerular disease category.

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