What is neonatal lupus erythematosus?

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What is neonatal lupus erythematosus?

2017-11-28 16:25

Characteristics of neonatal lupus erythematosus

Neonatal lupus erythematosus is characterized by skin lesions, cardiac block and serological abnormalities. Clinical two prominent manifestations of skin damage and congenital heart conduction block. NLE rash mainly manifested as annular erythema, with or without scales, similar to SCLE ring erythema damage, usually in about 1 month postpartum appear, for several months, histopathology and immunopathology consistent with the typical LE performance, the prognosis does not leave scar. Rash mainly in the head and neck, eyes and other exposure around the site, and then gradually developed to the chest, abdomen, back and other non-exposed parts.

The risk of neonatal lupus erythematosus on the heart

Neonatal lupus erythematosus heart damage, the most common is incomplete or complete atrioventricular block, according to statistics, the incidence of about 50% or more, and mostly complete atrioventricular block, the device Qualitative, often accompanied by life, and sometimes can occur alone without skin symptoms, in addition, the less common heart disease are: congestive heart failure, myocarditis, cardiomyopathy, large vascular ectopic, patent ductus arteriosus, , Ventricular septal, arteriovenous fistula and so on.

Risk factors of neonatal lupus erythematosus

The main risk factors of neonatal lupus erythematosus lupus erythematosus is the mother of anti Ro/SSA and anti La/SSB positive or dry syndrome patients, SLE risk of maternal anti Ro/SSA antibodies positive babies born NLE compared with nearly 20 times higher in patients with systemic lupus erythematosus, so against Ro / SSA and anti-La / SSB positive mother born to the baby should be immunological examination and follow-up, which can be early detection of neonatal lupus erythematosus.

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